Detail

Chr	chr22
start	30969245
end	30979395
lncRNA name	TUG1
entrez id	55000
hgnc id	HGNC:26066
ensg id	ENSG00000253352
refseq id	NR_002323
methods	qPCR, Western blotting etc.
regulated	down-regulated
function description	TUG1 overexpression significantly suppressed cell proliferation by causing cell cycle arrest and inducing apoptosis in breast cancer cells, while TUG1 knockdown caused increased cell growth via promoting cell cycle progression and regulating the expression of cyclinD1 and CDK4. Further functional assays indicated that TUG1 overexpression significantly promoted cell migration and invasion while TUG1 knockdown had the opposite effects. Our findings indicate that the lncRNA TUG1 is a tumor suppressor in breast cancer, and may serve as a novel prognostic biomarker and potential therapeutic target for patients with breast cancer.
pubmed id	28950664
year	2017
title	Downregulation of the long non-coding RNA TUG1 is associated with cell proliferation, migration, and invasion in breast cancer
drug	X
circulating	X
survival	V