Detail

Chr	chr14
start	95876392
end	95925571
lncRNA name	TUNAR
entrez id	100507043
hgnc id	HGNC:44088
ensg id	ENSG00000250366
refseq id	NR_038861
methods	qPCR, Western blot, RIP, ChIP, Luciferase reporter assay, RNA pull-down assay etc.
regulated	up-regulated
function description	We found the human ortholog of TUNA, linc00617, was upregulated in breast cancer samples. Linc00617 promoted motility and invasion of breast cancer cells and induced epithelial-mesenchymal-transition (EMT), which was accompanied by generation of stem cell properties. Moreover, knockdown of linc00617 repressed lung metastasis in vivo. We demonstrated that linc00617 upregulated the expression of stemness factor Sox2 in breast cancer cells, which was shown to promote the oncogenic activity of breast cancer cells by stimulating epithelial-to-mesenchymal transition and enhancing the tumor-initiating capacity
pubmed id	26207516
year	2015
title	Long noncoding RNA linc00617 exhibits oncogenic activity in breast cancer
drug	X
circulating	X
survival	X