Detail

Chr	chr19
start	15828206
end	15836326
lncRNA name	UCA1
entrez id	652995
hgnc id	HGNC:37126
ensg id	ENSG00000214049
refseq id	NR_015379
methods	qPCR, Western blot, Flow cytometry assay etc.
regulated	up-regulated
function description	LncRNA UCA1 was significantly upregulated in tamoxifen resistant breast cancer cells compared to tamoxifen sensitive cells. LCC2 and LCC9 cells transfected with UCA1 siRNA had significantly higher ratio of apoptosis after tamoxifen treatment. UCA1 siRNA significantly decreased the protein levels of p-AKT and p-mTOR in LCC2 and LCC9 cells. Enforced UCA1 expression substantially reduced tamoxifen induced apoptosis in MCF-7 cells, while rapamycin treatment abrogated the protective effect of UCA1.
pubmed id	27765938
year	2016
title	Long Non-Coding RNA (lncRNA) Urothelial Carcinoma-Associated 1 (UCA1) Enhances Tamoxifen Resistance in Breast Cancer Cells via Inhibiting mTOR Signaling Pathway.
drug	V
circulating	X
survival	X