Detail

Chr	chr19
start	15828206
end	15836326
lncRNA name	UCA1
entrez id	652995
hgnc id	HGNC:37126
ensg id	ENSG00000214049
refseq id	NR_015379
methods	qPCR, Western blot, Cell proliferation assay etc.
regulated	up-regulated
function description	We found that the expression of UCA1 positively correlated with the pathological grade and mortality of breast cancer patients, moreover, expressions of UCA1 was increased significantly in the tamoxifen-resistant cell lines compared with the wild type parental cells. Ectopic expression of UCA1 promoted cell survival and resistance to tamoxifen treatment, whereas inhibition of UCA1 enhanced tamoxifen sensitivity of BC cells and induced more apoptotic cells. In line with these data, UCA1 depletion attenuated the activity of Wnt/B-catenin pathway activation and the tumorigenicity of the tamoxifen-resistant BC cells.
pubmed id	27977766
year	2016
title	Knockdown of Long Non-Coding RNA UCA1 Increases the Tamoxifen Sensitivity of Breast Cancer Cells through Inhibition of Wnt/B-Catenin Pathway.
drug	V
circulating	X
survival	V