Detail

Chr	chrX
start	73820651
end	73852753
lncRNA name	XIST
entrez id	7503
hgnc id	HGNC:12810
ensg id	ENSG00000229807
refseq id	NR_001564
methods	qPCR, RNAi, IHC, ISH etc.
regulated	down-regulated
function description	Here, we show that Xist expression is significantly reduced in breast tumor samples and cancer cell lines. Xist knockdown or overexpression resulted in increased or decreased levels, respectively, of AKT phosphorylation and cell viability. Further studies revealed an inverse correlation between Xist and phospho-AKT levels in breast cancer samples. Additionally, Xist knockdown-elicited increase of cell viability was attenuated by AKT inhibitor. These results suggest that Xist negatively regulates cell viability via inhibition of AKT activation.
pubmed id	27248326
year	2016
title	Xist reduction in breast cancer upregulates AKT phosphorylation via HDAC3-mediated repression of PHLPP1 expression.
drug	X
circulating	X
survival	X