Detail

Chr	chrX
start	73820651
end	73852753
lncRNA name	XIST
entrez id	7503
hgnc id	HGNC:12810
ensg id	ENSG00000229807
refseq id	NR_001564
methods	qPCR, Western blot, Luciferase reporter assay etc.
regulated	up-regulated
function description	XIST was significantly down-regulated in breast cancer tissues and cell lines. Further functional analysis indicated that overexpression of XIST remarkably inhibited breast cancer cell growth, migration, and invasion.The results of luciferase reporter assays verified that miR-155 was a direct target of XIST in breast cancer. Moreover, caudal-type homeobox 1 (CDX1) was identified as a direct target of miR-155 and miR-155/CDX1 rescued the effects of XIST in breast cancer cells. Taken together,XIST is down-regulated in breast cancer and suppresses breast cancer cell growth, migration, and invasion via the miR-155/CDX1 axis.
pubmed id	29550489
year	2018
title	Long non-coding RNA XIST inhibited breast cancer cell growth, migration, and invasion via miR-155/CDX1 axis.
drug	X
circulating	X
survival	X