Detail

Chr	chr20
start	49278178
end	49295738
lncRNA name	ZFAS1
entrez id	441951
hgnc id	HGNC:33101
ensg id	ENSG00000177410
refseq id	NR_003604
methods	qPCR, Western blot etc.
regulated	down-regulated
function description	The results revealed that ZFAS1 expression was significantly downregulated in breast cancer cell lines when compared with the levels in controls. In vitro experiments also demonstrated that ZFAS1 overexpression significantly suppressed cell proliferation by causing cell cycle arrest and inducing apoptosis in breast cancer cells. Further functional assays indicated that ZFAS1 overexpression inhibited cell migration and invasion by regulating epithelial mesenchymal transition. These findings indicated that the lncRNA ZFAS1 may be a tumor suppressor in breast cancer, and thus, may serve as a potential therapeutic target for patients with breast cancer. ZFAS1 overexpression in MCF-7 and MDA-MB-231 cells resulted in significantly decreased clonogenic survival.
pubmed id	29532866
year	2018
title	Downregulation of the long non-coding RNA ZFAS1 is associated with cell proliferation, migration and invasion in breast cancer.
drug	X
circulating	X
survival	V