Detail

Chr	chr10
start	32900319
end	33005792
lncRNA name	linc-ITGB1
entrez id	NA
hgnc id	NA
ensg id	ENSG00000150093
refseq id	NA
methods	qPCR, RNAi, Western blot, Flow cytometry assay etc.
regulated	up-regulated
function description	The expression of linc-ITGB1 was significantly upregulated in both clinical breast cancer tissues and cultured breast cancer cell lines. Linc-ITGB1 depletion caused cell accumulation in the G0/G1 phase. Furthermore, the linc-ITGB1 knockdown decreased the expression of mesenchymal markers N-cadherin and vimentin while increasing the expression of the epithelial marker E-cadherin. Key cell cycle regulators Cdc25C and Cyclin B1 were also decreased by the linc-ITGB1 knockdown. These data suggest that linc-ITGB1 promotes breast cancer progression by inducing cell-cycle arrest and interrupting the epithelial-to-mesenchymal transition (EMT) process.
pubmed id	26601916
year	2015
title	Long non-coding RNA linc-ITGB1 promotes cell migration and invasion in human breast cancer.
drug	X
circulating	X
survival	X