Detail

Chr	chr18
start	57054558
end	57072119
lncRNA name	linc-ROR
entrez id	100885779
hgnc id	HGNC:43773
ensg id	ENSG00000258609
refseq id	NR_048536
methods	qPCR, Western blot, RIP etc.
regulated	up-regulated
function description	linc-RoR functions as an onco-lncRNA to promote estrogen-independent growth of ER+ breast cancer. Under estrogen deprivation, linc-RoR causes the upregulation of phosphorylated MAPK/ERK pathway which in turn activates ER signaling. Knockout of linc-RoR abrogates estrogen deprivation-induced ERK activation as well as ER phosphorylation, whereas re-expression of linc-RoR restores all above phenotypes. Moreover, we show that the ERK-specific phosphatase Dual Specificity Phosphatase 7 (DUSP7), also known as MKP-X, is involved in linc-RoR KOinduced repression of MAPK/ERK signaling. Interestingly, linc-RoR KO increases the protein stability of DUSP7, resulting in repression of ERK phosphorylation. Clinical data analysis reveal that DUSP7 expression is lower in ER+ breast cancer samples than that in ER- breast cancer. Moreover, downregulation of DUSP7 expression is associated with poor patient survival.
pubmed id	29041978
year	2017
title	Linc-RoR promotes MAPK/ERK signaling and confers estrogen-independent growth of breast cancer
drug	X
circulating	X
survival	V