Detail

Chr	chr9
start	86948699
end	87002033
lncRNA name	lncRNA-Hh
entrez id	100506834
hgnc id	HGNC:52261
ensg id	ENSG00000226237
refseq id	NA
methods	microarray, qPCR, Western blot, Luciferase reporter assay etc.
regulated	up-regulated
function description	The Shh-GLI1 pathway associated lncRNA-Hh, transcriptionally regulated by Twist, directly targets GAS1 to stimulate the activation of hedgehog signaling (Hh). The activated Hh increases GLI1 expression, and enhances the expression of SOX2 and OCT4 to play a regulatory role in CSC maintenance. Thus, the mammosphere-formation efficiency (MFE) and the self-renewal capacity in vitro, and oncogenicity in vivo in Twist-positive breast cancer cells are elevated. lncRNA-Hh silence in Twist-positive breast cells attenuates the activated Shh-GLI1 signaling and decreases the CSC-associated SOX and OCT4 levels, thus reduces the MFE and tumorigenesis of transplanted tumor.
pubmed id	26418365
year	2016
title	LncRNA-Hh Strengthen Cancer Stem Cells Generation in Twist-Positive Breast Cancer via Activation of Hedgehog Signaling Pathway.
drug	X
circulating	X
survival	X