Chr | NA |
start | NA |
end | NA |
strand | NA |
Geng Symbol | NA |
circRNA name | circAHNAK1 |
methods | qRT-PCR,Western blot,Luciferase assay,etc. |
regulated | Down? |
Function Description | In conclusion, circAHNAK1 is down-regulated in TNBC and its expression is negatively correlated with survival outcome in patients with TNBC. circAHNAK1 regulates TNBC cell proliferation and invasion, and the mechanism may be related to the expression of the tumor suppressor gene RASA1 by sponge miR-421, thereby promoting the progression of TNBC. The circAHNAK1-miR-421-RASA1 axis participates in TNBC progression through a competitive ceRNA mechanism. Therefore, circAHNAK1 can be used as a predictor of TNBC prognosis and a potential molecular target. |
PMID | 31857500 |
year | 2019 |
Title | CircAHNAK1 inhibits proliferation and metastasis of triple-negative breast cancer by modulating miR-421 and RASA1. |
drug | X |
circulating | X |
survival | V |
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