Detail

Chr	chr17
start	35800605
end	35800763
strand	+
Geng Symbol	TADA2A
circRNA name	hsa_circ_0006220
methods	qRT-PCR,etc.
regulated	Down?
Function Description	In summary, by using circRNA screening and functional verification together with clinical evidence, our study demonstrated the potential of two circTADA2As as promising prognostic biomarkers for breast cancer. Especially, circTADA2A-E6 functioned as a tumor suppressor by inhibiting cell proliferation, migration, and metastasis in breast cancer. Mechanistically, circTADA2A-E6 acted as a miR-203a-3p sponge restoring the expression of the miR-203a-3p target gene SOCS3. To the best of our knowledge, this is the first report thoroughly investigating the biological functions of circTADA2As and their clinical implications in breast cancer. This study may have a fundamental influence on breast cancer research, particularly for the identification of new biomarkers and future therapeutic targets paving the way for new pharmaceutical interventions for breast cancer.
PMID	30787278
year	2018
Title	circTADA2As suppress breast cancer progression and metastasis via targeting miR-203a-3p/SOCS3 axis
drug	V
circulating	X
survival	V