The Genomic Atlas of Breast Cancer — the non-coding theme
| Chr | NA |
| start | NA |
| end | NA |
| strand | NA |
| Geng Symbol | NA |
| circRNA name | circANKS1B |
| methods | qRT-PCR,RNAi,Luciferase assay,etc. |
| regulated | Up |
| Function Description | Results:CircANKS1B was significantly up-regulated in triple-negative breast cancer (TNBC) compared with non-TNBCtissues and cell lines. Increased circANKS1B expression was closely associated with lymph node metastasis andadvanced clinical stage and served as an independent risk factor for overall survival of breast cancer patients.Functional studies revealed that circANKS1B promoted breast cancer invasion and metastasis both in vitro andin vivo by inducing epithelial-to-mesenchymal transition (EMT), while had no effect on breast cancer growth.Mechanistically, circANKS1B abundantly sponged miR-148a-3p and miR-152-3p to increase the expression oftranscription factor USF1, which could transcriptionally up-regulate TGF-¦Â1 expression, resulting in activatingTGF-¦Â1/Smad signaling to promote EMT. Moreover, we found that circANKS1B biogenesis in breast cancerwas promoted by splicing factor ESRP1, whose expression was also regulated by USF1.Conclusions:Our data uncover an essential role of the novel circular RNA circANKS1B in the metastasis ofbreast cancer, which demonstrate that therapeutic targeting of circANKS1B may better prevent breast cancermetastasis |
| PMID | 30454010 |
| year | 2018 |
| Title | The pro-metastasis effect of cir-cANKS1B in breast cancer. |
| drug | X |
| circulating | X |
| survival | V |
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