Detail

Chr	NA
start	NA
end	NA
strand	NA
Geng Symbol	NA
circRNA name	hsa_circ_0072309
methods	luciferase assay,qRT-PCR,etc.
regulated	down
Function Description	Results: hsa_circ_0072309 expression in breast cancer tissues was upregulated relative to that in adjacent normal tissues. hsa_circ_0072309 could serve as a prognostic biomarker of breast cancer. hsa_circ_0072309 overexpression dramatically inhibited the proliferation, migration, and invasion of breast cancer cells in vitro. In vivo assays revealed that the ectopic expression of hsa_circ_0072309 repressed breast cancer growth. The results of our mechanistic studies indicated that hsa_circ_0072309 could act as the sponge of miR-492, which exhibited increased expression in breast cancer tissues. Hsa_circ_0072309 suppressed breast cancer cell proliferation, migration, and invasion by inhibiting miR-492.Conclusion: Our findings revealed for the first time that the hsa_circ_0072309-miR-492 axis plays an essential role in breast cancer progression.
PMID	30774431
year	2019
Title	Circular RNA hsa_circ_0072309 Inhibits Proliferation and Invasion of Breast Cancer Cells via Targeting miR-492
drug	X
circulating	X
survival	V