Detail

Chr	chr5
start	145197456
end	145205763
strand	-
Geng Symbol	PRELID2
circRNA name	hsa_circ_0006528
methods	qRT-PCR,luciferase assay,Western Blot,etc.
regulated	up
Function Description	As an emerging key player in the RNA world, circRNAs may widely affect life processes and various diseases, especially cancers. Based on our research results, we conclude that circ_0006528 was significantly upregulated in human breast cancer tissues and that aberrant circ_0006528 expression was significantly associated with advanced TNM stage and poor prognosis. Furthermore, circ_0006528 through the circ_0006528/miR-7-5p/Raf1/MAPK/ERK signalling pathway mediates the growth and metastasis of breast cancer, which provides theoretical and experimental insight into the role of circ_0006528 in breast cancer tumourigenesis and metastasis. Thus, circ_0006528 may serve as a biomarker for predicting prognosis and could be a new therapeutic target in targeted therapy for breast cancer.
PMID	30520151
year	2019
Title	hsa_circRNA_0006528 as a competing endogenous RNA promotes human breast cancer progression by sponging miR-7-5p and activating the MAPK/ERK signaling pathway.
drug	V
circulating	X
survival	V