Detail

Chr	NA
start	NA
end	NA
strand	NA
Geng Symbol	NA
circRNA name	circCcnb1
methods	microarray,etc.
regulated	Down?
Function Description	To explore the possibility of using circ-Ccnb1 as anagent for cancer therapy, we developed a peritoneal cancermodel by injecting cancer cells into the peritoneal cavity ofmice. This way, the tumor cells can readily spread every-where in the cavity forming a large number of small tumors.This approach mimics a number of cancers such as serousovarian carcinoma and lung cancer. It allows easy uptake ofnanoparticle conjugated circ-Ccnb1 expression plasmids.For large solid tumors, the efficiencies of plasmid uptakeare significantly lower than these small tumors. Advancedtechniques need to be developed to allow effective deliveryof plasmids, such as circ-Ccnb1, into solid tumors for futurecancer therapy.
PMID	29795334
year	2018
Title	Enhanced breast cancer progression by mutant p53 is inhibited by the circular RNA circ-Ccnb1.
drug	X
circulating	X
survival	V