Detail

Chr	NA
start	NA
end	NA
strand	NA
Geng Symbol	NA
circRNA name	circCDYL
methods	luciferase assay,qRT-PCR,etc.
regulated	up
Function Description	Results:An autophagy associated circRNA circCDYL was elevated by 3.2 folds in BC tissues as compared with theadjacent non-cancerous tissues, and circCDYL promoted autophagic level in BC cells via the miR-1275-ATG7/ULK1axis; Moreover, circCDYL enhanced the malignant progression of BC cells in vitro and in vivo. Clinically, increasedcircCDYL in the tumor tissues and serum of BC patients was associated with higher tumor burden, shorter survivaland poorer clinical response to therapy.Conclusions:circCDYL promotes BC progression via the miR-1275-ATG7/ULK1-autophagic axis and circCDYL couldact as a potential prognostic and predictive molecule for breast cancer patients
PMID	32213200
year	2020
Title	Autophagy-associated circRNA circCDYL augments autophagy and promotes breast cancer progression.
drug	X
circulating	X
survival	V