The Genomic Atlas of Breast Cancer — the non-coding theme
| Chr | NA |
| start | NA |
| end | NA |
| strand | NA |
| Geng Symbol | NA |
| circRNA name | circDENND4C |
| methods | qRT-PCR,Western blot,RIP,etc. |
| regulated | up |
| Function Description | Results:circDENND4C highly expressed in breast cancer was up-regulated in response to hypoxia. Knockdown ofcircDENND4C decreased glycolysis, migration and invasion in breast cancer cells under hypoxia. circDENND4C wasvalidated as a sponge of miR-200b and miR-200c. Deficiency of miR-200b or miR-200c reversed the suppressiveeffect of circDENND4C knockdown on breast cancer progression. Moreover, silence of circDENND4C reducedxenograft tumor growth by increasing miR-200b and miR-200c.Conclusion:circDENND4C silence suppresses glycolysis, migration and invasion in breast cancer cells underhypoxia by increasing miR-200b and miR-200c. |
| PMID | 31488193 |
| year | 2019 |
| Title | Knockdown of circDENND4C inhibits glycolysis, migration and invasion by up-regulating miR-200b/c in breast cancer under hypoxia. |
| drug | X |
| circulating | X |
| survival | V |
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