Detail

Chr	NA
start	NA
end	NA
strand	NA
Geng Symbol	NA
circRNA name	circEPSTI1
methods	Microarray,qRT-PCR,Luciferase assay,Western blot,etc.
regulated	differential expression
Function Description	Results: Knockdown of circEPSTI1 inhibits TNBC cell proliferation and induces apoptosis. In vitroand in vivo experiments indicated that circEPSTI1 binds to miR-4753 and miR-6809 as a miRNA sponge to regulate BCL11A expression and affect TNBC proliferation and apoptosis. High levels of circEPSTI1 correlate with reduced survival in TNBC patients. Conclusions:The circEPSTI1-miR-4753/6809-BCL11A axis affect the proliferation and apoptosis of triple-negative breast cancer through the mechanism of competing endogenous RNAs (ceRNA). In addition, our results identify circEPSTI1 as an independent prognostic marker for survival in patients with TNBC.
PMID	30083277
year	2018
Title	circEPSTI1 as a Prognostic Marker and Mediator of Triple-Negative Breast Cancer Progression.
drug	V
circulating	X
survival	V