Detail

Chr	NA
start	NA
end	NA
strand	NA
Geng Symbol	NA
circRNA name	circHMCU
methods	qRT-PCR,Luciferase assay,RIP,etc.
regulated	up
Function Description	In summary, our study found a circRNA, circHMCU, which was upregulated in breast 365 cancer tissues and correlated with poor prognosis. Further study revealed that 366 circHMCU could significantly promote proliferation and metastasis abilities of breast 367 cancer cells both in vitro and in vivo. Mechanistically, we found that circHMCU 368 could functioned as a microRNA sponge for let-7 family, which was validated by RIP 369 and luciferase reporter assay. Let-7 family is a well-known tumor suppressor because 370 of its formidable function and is considered as a potential diagnostic and prognostic 371 marker. Our study identified circHMCU as a microRNA sponge of let-7 family which 372 have important significance in understanding the regulatory function of let-7 in breast 373 cancer.
PMID	32330870
year	2020
Title	circHMCU Promotes Proliferation and Metastasis of Breast Cancer by Sponging the let-7 Family.
drug	X
circulating	X
survival	X