Detail

Chr	NA
start	NA
end	NA
strand	NA
Geng Symbol	NA
circRNA name	circKIF4A
methods	qRT-PCR,Luciferase Assay,RIP,Western Blot,etc.
regulated	up
Function Description	Results:qRT-PCR analyses verified that circKIF4A was significantly upregulated and positively associated with poorersurvival of TNBC. The inhibition of circKIF4A suppressed cell proliferation and migration in TNBC. Luciferase reporterassay and RNA immunoprecipitation assay revealed that circKIF4A and KIF4A could bind to miR-375 and thatcircKIF4A regulated the expression of KIF4A via sponging miR-375.Conclusions:The circKIF4A-miR-375-KIF4A axis regulates TNBC progression via the competitive endogenous RNA(ceRNA) mechanism. circKIF4A may therefore serve as a prognostic biomarker and therapeutic target for TNBC.
PMID	30744636
year	2019
Title	circKIF4A acts as a prognostic factor and mediator to regulate the progression of triple-negative breast cancer.
drug	X
circulating	X
survival	V