The Genomic Atlas of Breast Cancer — the non-coding theme
| Chr | NA |
| start | NA |
| end | NA |
| strand | NA |
| Geng Symbol | NA |
| circRNA name | circPLK1 |
| methods | Microarray,Luciferase assay,RNAi,Western blot,etc. |
| regulated | up |
| Function Description | This study showed that circPLK1 is significantly upregulated in TNBC and associated with worse clinical outcomes.CircPLK1 is found to regulatePLK1expression via binding to miR-296-5p as a sponge in TNBC cell proliferationand metastasis. Therefore, circPLK1 may serve as a potential biomarker for prognosis and promising target forTNBC therapy. |
| PMID | 31337246 |
| year | 2019 |
| Title | CircPLK1 sponges miR-296-5p to facilitate triple-negative breast cancer progression. |
| drug | X |
| circulating | X |
| survival | V |
CopyRight © University of Miami, USA; Harbin Medical University, China
