The Genomic Atlas of Breast Cancer — the non-coding theme
| Chr | NA |
| start | NA |
| end | NA |
| strand | NA |
| Geng Symbol | NA |
| circRNA name | circPLK1 |
| methods | Microarray,qRT-PCR,Luciferase assay,RNAi,Western blot,etc. |
| regulated | Up |
| Function Description | Results & conclusion:CircPLK1 was significantly upregulated in TNBC and associated with poor sur-vivals. CircPLK1 knockdown inhibited cell growth and invasionin vitroas well as tumor occurrence andmetastasisin vivo. CircPLK1-miR-296-5p-PLK1axis regulates tumor progression by ceRNA mechanism inTNBC, indicating that circPLK1 may serve as a prognostic factor and novel therapeutic target for TNBC |
| PMID | 31337246 |
| year | 2019 |
| Title | CircPLK1 sponges miR-296-5p to facilitate triple-negative breast cancer progression. |
| drug | X |
| circulating | X |
| survival | V |
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