The Genomic Atlas of Breast Cancer — the non-coding theme
| Chr | NA |
| start | NA |
| end | NA |
| strand | NA |
| Geng Symbol | NA |
| circRNA name | has_circ_069718 |
| methods | qRT-PCR,Western Blot,etc. |
| regulated | Down? |
| Function Description | Results: We found that circRNA_069718 expression was significantly increased in TNBC tissues and cell lines. High circRNA_069718 expression was significantly correlated with advanced TNM stage, lymph node metastasis, and poor overall survival of TNBC patients. Functionally, we showed that circRNA_069718 inhibition significantly reduced TNBC cells proliferation and invasion ability in vitro. Mechanically, we found that circRNA_069718 inhibition reduced the expression levels of Wnt/¦Â-catenin pathway-related genes (¦Â-catenin, c-myc, and cyclin D1).Conclusions: Our findings suggested that circRNA_069718 promoted TNBC progression via Wnt/¦Â-catenin pathway and could serve as a novel therapeutic target for TNBC treatment. |
| PMID | 31298383 |
| year | 2019 |
| Title | CircRNA_069718 promotes cell proliferation and invasion in triple-negative breast cancer by activating Wnt/beta-catenin pathway |
| drug | X |
| circulating | X |
| survival | V |
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