Detail

Chr	NA
start	NA
end	NA
strand	NA
Geng Symbol	NA
circRNA name	has_circ_100876
methods	qRT-PCR,Luciferase Assay,etc.
regulated	up
Function Description	RESULTS : QRT-PCR results showed that cir-cRNA_100876 level in BC tissues was conspic-uously higher than that in the adjacent tis-sues, and the patients with distant metasta-sis had higher expression than those without. Moreover, patients with a high expression of circRNA_100876 had a relatively lower over-all survival rate. Compared with the NC group, the cell proliferation and invasion ability of cir-cRNA_100876 knockdown group was conspic-uously decreased. QRT-PCR revealed that mi-croRNA-361-3p and circRNA_100876 showed a negative correlation in the expression level of genes in BC tissues. In addition, the results of the Luciferase reporter gene assay confirmed that circRNA_100876 can be targeted by microR-NA-361-3p through their binding site.CONCLUSIONS: High expression of cir-cRNA_100876 is conspicuously positively rele-vant to poor prognosis of BC patients. Addition-ally, circRNA_100876 is able to promote BC me-tastasis as well as proliferative capacity by mod-ulating microRNA-361-3p expression
PMID	31486496
year	2019
Title	CircRNA_100876 promote proliferation and metastasis of breast cancer cells through adsorbing microRNA-361-3p in a sponge form.
drug	X
circulating	X
survival	V