Detail

Chr	NA
start	NA
end	NA
strand	NA
Geng Symbol	NA
circRNA name	circTADA2As
methods	microarray,etc.
regulated	down
Function Description	They were consistently and significantlydecreased in a large cohort of breast cancer patients, and their downregulation was associated with poor patientsurvival for TNBC. Especially, circTADA2A-E6 suppressed in vitro cell proliferation, migration, invasion, andclonogenicity and possessed tumor-suppressor capability. circTADA2A-E6 preferentially acted as a miR-203a-3psponge to restore the expression of miRNA target geneSOCS3, resulting in a less aggressive oncogenic phenotype.circTADA2As as promising prognostic biomarkers in TNBC patients, and therapeutic targeting of circTADA2As/miRNA/mRNA network may be a potential strategy for the treatment of breast cancer.
PMID	30787278
year	2019
Title	circTADA2As suppress breast cancer progression and metastasis via targeting miR-203a-3p/SOCS3 axis.
drug	V
circulating	X
survival	V