Detail

Chr	NA
start	NA
end	NA
strand	NA
Geng Symbol	NA
circRNA name	circMTO1
methods	Western blot,etc.
regulated	down
Function Description	In conclusion, the results of the present study indicated a circRNA-involved regulatory pattern to mediate Eg5 protein expression during monastrol resistance. First, monastrol resis-tance induced downregulated circRNA-MTO1 expression in breast cancer cells. Second, overexpression of MTO1 repressed viability and reversed monastrol resistance through inhibiting Eg5 protein level and associating with TRAF4. Therefore, circRNA-MTO1 may be a functional regulatory factor of breast cancer, and restoration of MTO1 levels could be a future direction to overcome breast cancer chemoresistance.
PMID	30015883
year	2018
Title	Circular RNA?MTO1 suppresses breast cancer cell viability and reverses monastrol resistance through regulating the TRAF4/Eg5 axis.
drug	V
circulating	X
survival	V