Detail

Chr	chr5
start	49694940
end	49707217
strand	-
Geng Symbol	EMB
circRNA name	hsa_circ_0001481
methods	qRT-PCR,etc.
regulated	up
Function Description	Results: A total of 215 upregulated and 191 downregulated circRNAs were identified. The expression levels of ten randomly selected majorly altered circRNAs were re-examined by real-time quantitative PCR and agarose gel electrophoresis, and the following alterations were verified: upregulation of hsa_circ_0001944, hsa_circ_0001481, hsa_circ_0000646, hsa_circ_0001006 and hsa_circ_0000732, and downregulation of hsa_circ_0001910, hsa_circ_0008285 and hsa_circ_0000002. CircRNA/miRNA analysis revealed that hsa_circ_0001944 may be involved in BCBM through sponging up miR-509 and interfering with its binding to the downstream targets.Conclusion: This study provides a leading and fundamental circRNA profile of BCBM.
PMID	30810051
year	2018
Title	Circular RNA profile of breast cancer brain metastasis: identification of potential biomarkers and therapeutic targets.
drug	X
circulating	X
survival	X