The Genomic Atlas of Breast Cancer — the non-coding theme
| Chr | chr19 |
| start | 17448965 |
| end | 17449496 |
| strand | - |
| Geng Symbol | GTPBP3 |
| circRNA name | hsa_circ_0000911 |
| methods | qRT-PCR,luciferase assay,RIP,Western blot,etc. |
| regulated | Down? |
| Function Description | In conclusion, in this study, and to the best of our knowledge, we report for the first time that circRNA-000911 plays an anti-oncogenic role in breast cancer. Moreover, circRNA-000911 exerts its function by serving as a miRNA sponge for miR-449a and thereby promoting the function of Notch1 and the NF-¦ĘB signaling pathway. Therefore, circRNA-000911 may serve as a promising predictive biomarker and therapeutic target for patients with breast cancer. |
| PMID | 29431182 |
| year | 2018 |
| Title | Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-000911/miR-449a pathway in breast carcinogenesis |
| drug | X |
| circulating | V |
| survival | V |
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