Detail

Chr	chr20
start	30345209
end	30370193
strand	+
Geng Symbol	TPX2
circRNA name	hsa_circ_0001135
methods	Microarray,qRT-PCR,luciferase assay,etc.
regulated	Down
Function Description	ncRNAs are dysregulated in breast cancer and miRNAs, noted for their stability, and lncRNAs arebeing investigated as biomarkers of disease pathology, prognostic indicators, and potential therapeutictargets, as well as modalities to block cancer progression and metastasis. We know much moreabout miRNAs than lncRNAs in human breast tumors. Our understanding of the networks betweenmiRNAs, lncRNAs, their interacting partners, and targets is expanding. However, individual andcombinations of miRNAs and lncRNAs have cell-specific activities that are not fully understood,nor is their interaction with the immune system, microbiome, microenvironment, hormonal milieu,or metabolome elucidated. Further investigation is needed to bring studies on miRNAs and lncRNAsinto clinical practice for diagnosis, prognosis, and therapeutics in breast cancer patients
PMID	30545127
year	2018
Title	Circular RNA hsa_circ_0001982 promotes breast cancer cell carcinogenesis through decreasing miR-143
drug	X
circulating	X
survival	V