Detail

Chr	NA
start	NA
end	NA
strand	NA
Geng Symbol	NA
circRNA name	circAGFG1
methods	qRT-PCR,microarray,FISH,luciferase assay,Western blot,RIP,etc.
regulated	Down?
Function Description	Results:We found that circAGFG1 was evidently up-regulated in TNBC, and its level was correlated with clinicalstage, pathological grade and poor prognosis of patients with TNBC. The results indicated that circAGFG1 couldpromote TNBC cell proliferation, mobility and invasion as well as tumorigenesis and metastasis in vivo.Mechanistic analysis showed that circAGFG1 may act asa ceRNA (competing endogenous RNA) of miR-195-5p torelieve the repressive effect of miR-195-5p on its target cyclin E1 (CCNE1).Conclusions:Our findings suggest that circAGFG1 promotes TNBC progression through circAGFG1/miR-195-5p/CCNE1 axis and it may serve as a new diagnostic marker or target for treatment of TNBC patients.
PMID	30621700
year	2019
Title	The circRNA cir-cAGFG1 acts as a sponge of miR-195-5p to promote triple-negative breast cancer progression through regulating CCNE1 expression.
drug	X
circulating	X
survival	V