Detail

Chr	chr21
start	16386664
end	16415895
strand	-
Geng Symbol	NRIP1
circRNA name	hsa_circ_0004771
methods	Luciferase assay,RT-qPCR,Western blot,etc
regulated	up
Function Description	In conclusion, our findings suggested that miR-653 was able to target both hsa_circ_0004771 and ZEB2, reflecting that hsa_circ_0004771 might serve as miR-653 sponge to modulate ZEB2 expression through the ceRNA mechanism. Bioinformatics prediction and luciferase reporter assays verified these conclusions. We also found that hsa_circ_0004771 performed a parallel effect to ZEB2 and an opposite effect to miR-653 in breast cancer cell proliferation and apoptosis. More importantly, hsa_circ_0004771/miR-653/ZEB2 aixs contributed to the development of the new therapeutic targets for the treatment of breast cancer.
PMID	30979827
year	2019
Title	Silencing of hsa_circ_0004771 inhibits proliferation and induces apoptosis in breast cancer through activation of miR-653 by targeting ZEB2 signaling pathway.
drug	X
circulating	X
survival	V