The Genomic Atlas of Breast Cancer — the non-coding theme
| Chr | chr10 |
| start | 117849251 |
| end | 117856275 |
| strand | - |
| Geng Symbol | GFRA1 |
| circRNA name | hsa_circ_0005239 |
| methods | Microarray,qRT-PCR,Luciferase assay,RIP,Western blot,etc. |
| regulated | up |
| Function Description | Taken together, our study indicates that circGFRA1 isupregulated and correlated with poor clinical outcomes inTNBC. circGFRA1 could promote proliferation and inhibitapoptosis in TNBC. And circGFRA1 functions as aceRNA to regulate GFRA1 expression by decoyingmiR-34a in TNBC progression. circGFRA1 can beused as a diagnostic biomarker and potential target inTNBC therapy. |
| PMID | 29037220 |
| year | 2017 |
| Title | circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a |
| drug | X |
| circulating | X |
| survival | V |
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