Detail

Chr	chr2
start	176150303
end	176150412
ID	MI0000267
miRNA_name	hsa-miR-10b
methods	qRT-PCR,Microarray,etc.
regulated	down
Function Description	In summary, we have presented, for the first time, a luminal mammary cancer progression-associated miRNA profile and have shown that CR prevents the dysregulation of one of thesemiRNA, miR-200a. Further, we have shown that CR greatly reduces tumor initiation andgrowth, a protective effect that can be explained, at least in part, through CR��s normalization ofmiR-200a expression and resultant inhibition of cellular proliferation. These findings deepenour understanding of the dysregulation of miRNA throughout cancer progression and suggestthat miR-200a may be a novel intervention target for mimicking the suppressive effects of CRon mammary tumor development and growth.
PMID	27433802
year	2016
Title	Stage-Specific MicroRNAs and Their Role in the Anticancer Effects of Calorie Restriction in a Rat Model of ER-Positive Luminal Breast Cancer
drug	X
circulating	X
survival	V