The Genomic Atlas of Breast Cancer — the non-coding theme
| Chr | NA |
| start | NA |
| end | NA |
| ID | NA |
| miRNA_name | hsa-miR-302 |
| methods | etc. |
| regulated | down |
| Function Description | Results: Ectopic expression of miR-302/367 cluster downregulated expression of some downstream elements of TGF-¦Â pathway in MDA-MB-231 and SK-BR-3 breast cancer cell lines. Overexpression of miR-302/367 cluster inhibited proliferation of the breast cancer cells by suppressing the S-phase of cell cycle which was in accordance with inhibition of TGF-¦Â pathway. Conclusion: TGF-¦Â signaling is one of the key pathways in tumor progression and a general suppression of TGF-¦Â mediators by the pleiotropically acting miR-302/367 cluster may be one of the important reasons for its anti-tumor effects in breast cancer cells. |
| PMID | 31376326 |
| year | 2020 |
| Title | Repression of TGF-¦Â Signaling in Breast Cancer Cells by miR-302/367 Cluster. |
| drug | X |
| circulating | X |
| survival | X |
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