Detail

Chr	NA
start	NA
end	NA
ID	NA
miRNA_name	hsa-miR-106
methods	qRT-PCR,RNA-seq,etc.
regulated	up
Function Description	In our study, there was still some weakness that deservesto be acknowledged. First, the molecular mechanisms by whichmiR-106b and EMT-related molecules in CTCs regulate tumorprogression were not presented in this study. However, several reasons are responsible for this limitation. As far as we know,the isolation and enrichment as well as ex vivo culture of viableCTCs are still technically challenging, and the frequency of CTCin the peripheral blood of patients with solid tumors variesamong individual patients with different prior systemic thera-pies. In recent years, although a few papers reported that thegenome alternation of CTC lines and suspended cancer cellsmay be related to the drug sensitivity in both in vitro and xeno-grafts models in breast cancer [53], the evidence is indirect andnot strong enough because of the above limitations. Second,the downstream targeted molecules of miR-106b related toEMT should be further tested in our future studies.
PMID	31300482
year	2019
Title	Incorporating MicroRNA Into Molecular Phenotypes of Circulating Tumor Cells Enhances the Prognostic Accuracy for Patients With Metastatic Breast Cancer
drug	V
circulating	V
survival	V