Detail

Chr	NA
start	NA
end	NA
ID	NA
miRNA_name	hsa-miR-105
methods	qRT-PCR,etc
regulated	up
Function Description	Results:Before neoadjuvant therapy, exosomal miRNA-21 and 105 expression levels were higher in metastaticversus non-metastatic patients and healthy donors. Likewise, higher levels of miRNA-222 were observed in basal-like(p= 0.037) and in luminal B versus luminal A (p= 0.0145) tumor subtypes. Exosomal miRNA-222 levels correlatedwith clinical and pathological variables such as progesterone receptor status (p= 0.017) and Ki67 (p= 0.05). Duringneoadjuvant treatment, exosomal miRNA-21 expression levels directly correlated with tumor size (p= 0.039) andinversely with Ki67 expression (p= 0.031). Finally, higher levels of exosomal miRNA-21, miRNA-222, and miRNA-155were significantly associated with the presence of circulating tumor cells.Conclusion:Liquid biopsies based on exosomal miRNAs and circulating tumor cells can be a complementaryclinical tool for improving breast cancer diagnosis and prognosis
PMID	30728048
year	2019
Title	Exosomal miRNA profile as complementarytool in the diagnostic and prediction oftreatment response in localized breastcancer under neoadjuvant chemotherapy
drug	X
circulating	V
survival	X