Detail

Chr	chr7
start	130496111
end	130496204
ID	MI0000816
miRNA_name	hsa-miR-335
methods	qRT-PCR,etc.
regulated	down
Function Description	Results: A significant decrease in miRNA-335 expression was reported in patients with breast cancer as compared to the other two investigated groups. The positivity rate for miRNA were related to adverse clinical features of primary breast cancer as high histological grading (X2 = 7.72, P = 0.016), presence of metastasis to lymph node (X2 = 21.8, P < 0.001), large tumor size (X2 = 6.41, P = 0.041), and hormonal status (P < 0.001). miRNA-335 mean rank level was significantly different among breast cancer subtypes and its level was inferior in triple negative breast cancer. Worse DFS (X2 = 7.76, P = 0.005) and OS (X2 = 9.3, P = 0.002) were reported with decreased miRNA-335 level.Conclusion: Assessment of circulating miRNA expression level is a promising minimal invasive marker for diagnosis and prediction of breast cancer prognosis with significant discrepancies among molecular breast cancer subtypes.
PMID	30506730
year	2019
Title	Clinical Aspects of Circulating miRNA-335 in Breast Cancer Patients: A Prospective Study
drug	X
circulating	V
survival	X