Detail

Chr	chrX
start	45747015
end	45747124
ID	MI0000299
miRNA_name	hsa-miR-222
methods	qRT-PCR,microarray,etc.
regulated	up
Function Description	Results: Based on the results of microRNA profiling, seven miRNAs were selected for further validation. In the HR+/HER2- cohort (n = 51) dynamics of three miRNAs, including miR-222, miR-20a, and miR-451, were associated with chemo-sensitivity. Importantly, across all the three subtypes we consistently identified chemo-induced decrease in plasma miR-34a in the insensitive patients. Finally, baseline miR-222 overexpression (OR = 6.422, P = 0.049), C2 miR-20a up-regulation (OR = 0.144, P = 0.021) and C2 miR-451 down-regulation (OR = 8.213, P = 0.012) were predictive markers of response to NCT in HR+/HER2- breast cancer.Conclusions: We described that dynamics of circulating miRNAs might help predict clinical response to NCT in breast cancer.
PMID	30099860
year	2018
Title	Dynamics of Circulating microRNAs as a Novel Indicator of Clinical Response to Neoadjuvant Chemotherapy in Breast Cancer
drug	X
circulating	V
survival	X